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Salvia miltiorrhiza Extract Introduction

Edit by Yongyuan Bio Kiki 20191206

In ChP, USP, and EP, Danshen refers to the dried roots and rhizomes of Salvia miltiorrhiza Bge.


More than 70 components of salvia miltiorrhiza have been separated and purified and can be divided into liposoluble and water-soluble compounds. There are about 27 water-soluble phenolic acid derivatives. The main active ingredients are salvianolic acids including A-K (Salvianolic acids A-K), rosemary acid, etc .; liposoluble components of salvia miltiorrhiza have been identified more than 50 diterpenoid compounds, most of which are tanshinones, including Tanshinone I, Tanshinone Ⅱ A, Tanshinone ⅡB, etc., and Tanshinone ⅡA accounts for 0.1 ~ 0.9% of the medicinal materials, and it is also the main liposoluble active ingredient.
 
At present, the water-soluble components isolated from Salvia miltiorrhiza are mainly phenolic compounds such as 3- (3,4-dihydroxyphenyl) lactic acid, Salvianolic acid B, and protocatechuic aldehyde, caffeic acid, rosmarinic acid, etc.; liposoluble components are mainly conjugated, ketone compounds such as tanshinone, tanshinone ⅡA, cryptorytanshinone, and so on. Modern pharmacological research shows that most of the water-soluble components of salvia miltiorrhiza have anti-oxidant, anticoagulant, and anti-myocardial ischemia effects, which are closely related to traditional functions such as "blood circulation and blood stasis"; while liposoluble components mainly containing tanshinones which have antibacterial properties, Anti-inflammatory effect, and functions of nervous system protection, anti-myocardial ischemia, myocardial protection and endothelial cell protection.
 
Different origins, different harvest times, and different extraction methods lead to significant differences in the distribution of active ingredients in Salvia miltiorrhiza.
 
Extraction Water Extracion Methonal Extraction Supercritical Extraction Atomization Extraction
Active ingredients Mainly water-soluble ingredients, almost no hydrophobic components Mainly hydrophobic components,  less water-soluble components Mainly hydrophobic components Reasonable distribution of water-soluble ingredients and hydrophobic components
Pros and cons Low cost, Many impurities, large damage to effective ingredients Less impurities and high cost Good product properties and high cost High efficiency and environmentally friendly, high utilization rate of medicinal materials, Hi-tech, High production capacity
 
Water-soluble salvianolic acids are mainly salvianolic acid B, which is one of the most studied salvianolic acids. Salvianolic acid B has anti-oxidant effects, can remove free radicals in the body and inhibit lipid peroxidation. It is one of the best known natural antioxidant compounds, and its antioxidant capacity is higher than common antioxidants such as vitamin C, vitamin E, and mannitol. In addition, salvianolic acid B also protects brain ischemia, reduces myocardial and cardiac microvascular ischemia-reperfusion injury, and prevents atherosclerotic plaque formation; salvianolic acid A is used for angina pectoris, acute myocardial infarction, and retina Central arterial embolism.
The liposoluble compound contains cryptotanshinone, which has anti-oxidant and anti-aging functions, and it has a certain effect on angina pectoris and myocardial damage. Furthormore, it also has a bacteriostatic effect. Tanshinone ⅡA can improve coronary circulation, inhibit thrombosis and improve arrhythmia. However, because tanshinone ⅡA is not easily soluble in water, sodium tanshinone ⅡA SilateA, a water-soluble substance obtained by sulfonation, can overcome this shortcoming makes Tanshinone IIA soluble in water without loss of its function. Many studies have also modified Tanshinone to modify its biological activity.
Specifications we work with Salvia miltiorrhiza Extract
Item Spec Test Method Application
Tanshinone IIA 1%-98% HPLC Danshen Tablet/Capsule
Healthcare food, Cosmetics
Sodium Tanshinone IIA Sulfonate 98% UV Injection, Healthcare food, Cosmetics
Total Tanshinones 10%-98% UV Healthcare food
Tanshinone I 95% HPLC Pharma
Salvianolic Acid B 5%-60% HPLC Danshen Tablet/ granules
Healthcare food, Beverage
Salvia Extract Salvianolic Acid B 7%, Tanshinone IIA 0.3% HPLC Compound tablets
Total Salvianolic Acids 10%-90% UV Used for Powder-Injection
Cryptotanshinone 10%-95% HPLC Healthcare food, Chinese patent drug, Capsules, Cosmetics
Salvianic Acid A 5%-98% HPLC Danshen Tablet/Capsules/Droping pills
Salvianic Acid A Sodium 5%-98% HPLC Injection Grade
Salvia Extract Rosmarinic acid 0.5%, Salvianolic Acid B 5% HPLC Danshen Tablet/ granules
Healthcare food
Other customized specifications.
 

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